![]() Where 60 represents MW of urea and 14*2 MW of urea nitrogen. Elsewhere, the concentration of urea is reported in SI units as mmol/L.ī U N m g / d L High BUN levels can also be caused by low blood flow to the kidneys caused by dehydration or heart. Kidney damage can be caused by diabetes or high blood pressure that directly affects the kidneys. A high BUN value can mean kidney injury or disease is present. United States, Mexico, Italy, Austria, and Germany). A value that isnt in the normal range may still be normal for you. ![]() OTC deficiency is also accompanied by hyperammonemia and high orotic acid levels.īUN is usually reported in mg/dL in some countries (e.g. Reference ranges for blood tests, comparing urea (yellow at right) to other blood constituentsĪnother rare cause of a decreased BUN is ornithine transcarbamylase deficiency, which is a genetic disorder inherited in an X-linked recessive pattern. The main causes of a decrease in BUN are malnutrition (low-protein diet), severe liver disease, anabolic state, and syndrome of inappropriate antidiuretic hormone. Hypothyroidism can cause both decreased GFR and hypovolemia, but BUN-to-creatinine ratio has been found to be lowered in hypothyroidism and raised in hyperthyroidism. The main causes of an increase in BUN are: high-protein diet, decrease in glomerular filtration rate (GFR) (suggestive of kidney failure), decrease in blood volume ( hypovolemia), congestive heart failure, gastrointestinal hemorrhage, fever, rapid cell destruction from infections, athletic activity, excessive muscle breakdown, and increased catabolism. The normal range is 2.1–7.1 mmol/ L or 6–20 mg/ dL. Interpretation īUN is an indication of kidney health. It is not considered as reliable as creatinine or BUN-to-creatinine ratio blood studies. The test is used to detect kidney problems. ![]() Individual laboratories may have different reference ranges, as they may use different assays. Normal human adult blood should contain 7 to 18 mg/dL (0.388 to 1 mmol/L) of urea nitrogen. The liver produces urea in the urea cycle as a waste product of the digestion of protein. 6299-2, 59570-2, 12961-9, 12963-5, 12962-7īlood urea nitrogen ( BUN) is a medical test that measures the amount of urea nitrogen found in blood.
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